复杂疾病特征筛选及预测模型研究
基于人工智能算法的药物重定位方法研究
临床试验设计评价方法研究
1.国家自然科学基金面上项目(81773550)《基于深度神经网络的动态多模态数据特征提取及其应用研究》(2018/01-2021/12),主持。
2.国家自然科学基金面上项目(81573256)《基于结构组稀疏算法的多尺度高维数据变量筛选及预测模型研究》(2016/01-2019/12),主持。
3.国家自然科学基金青年项目(81102201)《基于抗肿瘤新药多阶段设计的P-P曲线模型与分析方法研究》(2012/01-2014/12),主持。
4.黑龙江省留学归国择优资助项目《基于结构组稀疏算法的多时间点宫颈癌化疗敏感性预测模型及验证研究》(2018/01-2020/12),主持。
5.国家自然科学基金面上项目(81473072)《基于网络解卷积和贝叶斯模型的组学数据融合分析方法及应用研究》(2015/01-2018/12),参加。
1. Cao L, Yang J, Rong Z, Li L, Xia B, You C, Lou G, Jiang L, Du C, Meng H, Wang W, Wang M, Li K, Hou Y. A novel attention-guided convolutional network for the detection of abnormal cervical cells in cervical cancer screening. Medical Image Analysis. 2021.
2. Sun Y, Hou Y, Lv N, Liu Q, Lin N, Zhao S, Chu X, Chen X, Cheng G, Li P. Circulating lncRNA BC030099 Increases in Preeclampsia Patients. Molecular Therapy-Nucleic Acids. 2019; 14:562-6.
3. Zhao W, Zhao F, Yang K, Lu Y, Zhang Y, Wang W, Xie H, Deng K, Yang C, Rong Z, Hou Y, Li K. An immunophenotyping of renal clear cell carcinoma with characteristics and a potential therapeutic target for patients insensitive to immune checkpoint blockade. Journal of cellular biochemistry. 2019; 120(8): 13330-13341.
4. Yang C, Zhang M, Cai Y, Rong Z, Wang C, Xu Z, Xu H, Song W, Hou Y, Lou G. Platelet-derived growth factor-D expression mediates the effect of differentiated degree on prognosis in epithelial ovarian cancer. Journal of Cellular Biochemistry. 2019;120(5):6920-5.
5. Lu X, Li Y, Xia B, Bai Y, Zhang K, Zhang X, Xie H, Sun F, Hou Y, Li K. Selection of small plasma peptides for the auxiliary diagnosis and prognosis of epithelial ovarian cancer by using UPLC/MS-based nontargeted and targeted analyses. International Journal of Cancer. 2019;144(8):2033-42.
6. Zhang F, Zhang Y, Ke C, Li A, Wang W, Yang K, Liu H, Xie H, Deng K, Zhao W, Yang C, Lou G, Hou Y, Li K. Predicting ovarian cancer recurrence by plasma metabolic profiles before and after surgery. Metabolomics. 2018;14(5).
7. Wang C, Yang C, Wang W, Xia B, Li K, Sun F, Hou Y. A Prognostic Nomogram for Cervical Cancer after Surgery from SEER Database. Journal of Cancer. 2018;9(21):3923-8.
8. Deng K, Yang C, Tan Q, Song W, Lu M, Zhao W, Lou G, Li Z, Li K, Hou Y. Sites of distant metastases and overall survival in ovarian cancer: A study of 1481 patients. Gynecologic Oncology. 2018;150(3):460-5.
9. Ke C, Hou Y, Zhang H, Fan L, Ge T, Guo B, Zhang F, Yang K, Wang J, Lou G, Li K. Large-scale profiling of metabolic dysregulation in ovarian cancer. International Journal of Cancer. 2015;136(3):516-26.
10. Hou Y, Yin M, Sun F, Zhang T, Zhou X, Li H, Zheng J, Chen X, Li C, Ning X, Lou G, Li K. A metabolomics approach for predicting the response to neoadjuvant chemotherapy in cervical cancer patients. Molecular Biosystems. 2014;10(8):2126-33.