随机过程和统计学与物理、化学、生物的交叉

1、 与非平衡态统计物理有关的概率论和随机过程数学理论研究；

2、高维统计学习在生物上的应用，主要解决实际的生物学数据分析问题；

3、随机动力学模型在生物学上的应用，主要针对单细胞层面的动力学问题。

1. 国家自然科学基金青年项目(10901040，2010-2012):　随机过程在现代非平衡统计物理及生物化学模型中的应用　主持 16万；

2. 全国优秀博士学位论文专项资助(2011-2015)：生物化学和统计物理中的随机过程模型研究主持 56万；

3. 国家自然科学基金面上项目(21373021，2014-2017):　由DNA介导的别构效应祥光理论与模型研究 主持 60万；

4. 科技部863计划(2015AA020406, 2015-2017)：单细胞实时动态三维成像新技术及装置研究 参与  60万；

5. 国家自然科学基金委优秀青年项目(11622101，2017-2019)：随机过程与生物物理化学的交叉学科研究 主持 130万;

1.You, Z.Y., Li, L.Y., Lu, J.F. * and Ge, H. *: Integrated tempering enhanced sampling method as the infinite switching limit of simulated tempering. J. Chem. Phys. 149, 084114 (2018) (*co-corresponding authors)

2.Gao, S., …, Ge, H. *, Qiao, J. * and Tang, F.C. *: Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing. Nat. Cell Biol. 20, 721–734 (2018) (*co-corresponding authors)

3.Ge, H., Wu, P.P., Qian, H. and Xie, X.S.: Relatively slow stochastic gene-state switching in the presence of positive feedback significantly broadens the region of bimodality through stablizing the uninduced phenotypic state. Plos Comput. Biol. 14(3): e1006051 (2018)

4.Ge, H., Jiang, D.Q. and Jia, C.: Cycle symmetry, limit theorems, and fluctuation theorems for diffusion processes on the circle. Stoc. Proc. Appl. 127: 1897–1925 (2017)

5.Zhao, Z.Q., Xie, X.S. * and Ge, H. *: Nonequilibrium Relaxation of Conformational Dynamics Facilitates Catalytic Reaction in an Elastic Network Model of T7 DNA Polymerase. J. Phys. Chem. B 120, 2869−2877 (2016) (*co-corresponding authors)

6.Ge, H., Qian, H. and Xie, X.S.: Stochastic phenotype transition of a single cell in an intermediate region of gene state switching. Phys. Rev. Lett. 114, 078101 (2015)

7.Chong, S.S., Chen, C.Y., Ge, H. and Xie, X.S.: Mechanism of transcriptional bursting in bacteria. Cell 158, 314–326 (2014)

8.Ge, H., Qian, M. and Qian, H.: Stochastic theory of nonequilibrium steady states. Part II: Applications in chemical biophysics. Phys. Rep. 510, 87-118 (2012)

9.Ge, H. and Qian, H.: The physical origins of entropy production, free energy dissipation and their mathematical representations. Phys. Rev. E 81 051133 (2010)

10.Ge, H. and Qian, H.: Thermodynamic limit of a nonequilibrium steady state: Maxwell-type construction for a bistable biochemical system. Phys. Rev. Lett. 103, 148103 (2009)