1.细胞与计算毒理学:中药成分毒性的早期预测
2.药物毒理学:药物代谢和毒性机制
3.生态毒理学:自然环境中大气污染物对人体健康的影响
1. 2022-2025年,国家自然科学基金面上项目(82174068):基于靶点“钩钓”技术的朱砂靶蛋白发现和神经药理/毒理机制研究,项目负责人
2. 2019-2021年,国家重点研发计划课题(2018YFC1004301):基于外暴露监测的环境和行为因素对胚胎发育与妊娠影响的队列研究,课题负责人
3. 2017-2020年,国家自然科学基金面上项目(81673685):小儿中成药“一捻金”中朱砂的潜在神经发育毒性及配伍减毒研究,项目负责人
4. 2014-2016年,教育部博士点基金 (20130001110065):补骨脂酚CYP代谢与毒性的分子机制研究,项目负责人
5. 2014年,国家自然科学基金主任基金(81341089):基于代谢相互作用的补骨脂-甘草配伍的适宜性研究,项目负责人
6. 2008-2011年,国家科技支撑计划重大项目(2007BAC03A10):“执行<联合国防治荒漠化公约> 的支撑技术研究与示范”专题“风沙灾害对人体健康的影响评价”,专题负责人
7. 2007-2009年,国家自然科学基金(30672653):朱砂在消化道中物种转化与药效毒性相关性研究,项目负责人
1. Zhang T, Wang S, Li L, Zhu A, Wang Q*. Associating diethylhexyl phthalate to gestational diabetes mellitus via adverse outcome pathways using a network-based approach. Sci Total Environ. 2022, 824:153932
2. Yuqing Sun, Xin Zhang, Xiaofan Shen, Shuo Wang, Qi Wang*, Xiuwei Yang *. Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins. Eur J Pharmacol, 2021, 908:174372
3. Jingwei Zhao, An Zhu, Yuqing Sun, Wenjing Zhang, Tao Zhang, Yadong Gao, Danping Shan, Shuo Wang, Guojun Li, Kewu Zeng*, Qi Wang*, Beneficial effects of sappanone A on lifespan and thermotolerance in Caenorhabditis elegans. Eur J Pharmacol, 2020, 888: 173558
4. Mimi Yang, Lichao Wang, Tao Zhang, An Zhu, Yuqing Sun, Jingwei Zhao, Dan Liu, Qi Wang*, Kewu Zeng*. Different proteomic profiles of cinnabar upon therapeutic and toxic exposure reveal distinctive biological manifestations. J Ethnopharmacol, 2020, 112668.
5. An Zhu, Zonghui Ji, Jingwei Zhaoa, Wenjing Zhangb,c, Yuqing Suna, Tao Zhanga, Shan Gaob, Guojun Li*, Qi Wang*. Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans. Phytomedicine,2019, 65: 153102
6. Jinlan Yang, An Zhu, Shuo Xiao, Tao Zhang, Liming Wang, Qi Wang*, Lifeng Han*. Anthraquinones in the aqueous extract of Cassiae semen cause liver injury in rats through lipid metabolism disorder. Phytomedicine,2019, 64: 153059
7. Yuqing Sun, Shaoze Shi, Yaqiu Li, Qi Wang*. Development of quantitative structure-activity relationship models to predict potential nephrotoxic ingredients in traditional Chinese medicines. Food Chem Toxicol, 2019, 128: 163-170
8. An Zhu, Yuqing Sun, Qianwen Zhong, Jinlan Yang, Tao Zhang, Jingwei Zhao, Qi Wang*. Effect of Euphorbia factor L1 on oxidative stress, apoptosis and autophagy in human gastric epithelial cells. Phytomedicine,2019, 64: 152929
9. An Zhu, Tao Zhang, Qi Wang*. The phytochemistry, pharmacokinetics, pharmacology and toxicity of Euphorbia semen. J Ethnopharmacol, 2018, 227: 41-55
10. Xiaojing Hu, Youbo Zhang, Lei Zhang, Qi Wang*, Xiu-Wei Yang*. Metabolic detoxification of bakuchiol is mediated by oxidation of CYP 450s in liver microsomes. Food Chem Toxicol, 2018, 111: 385-392