职业与环境有害因素致病机制及防治研究(含纳米毒理学、重金属健康风险评估、生物监测与生物标志研究以及多组学技术联合应用等)。
1. 国家自然科学基金联合基金重点项目资助“基于免疫调节的铬酸盐职业暴露早期遗传损伤及修复机制研究”(2021-2024),负责人。
2. 国家自然科学基金面上项目资助“基于联合组学技术的铬酸盐职业接触致呼吸系统损伤及修复机制研究”(2019-2022),负责人。
3. 国家自然科学基金重大研究计划培育项目“大气颗粒物(PM2.5)及有效组分对大鼠遗传物质损伤及修复的影响”(2018-2020),负责人。
4. 国家自然科学基金面上项目资助“基因环境交互作用对铬酸盐所致遗传损伤的机制研究”(2016-2019),负责人。
5. 国家自然科学基金面上项目资助“基于分子暴露组学的铬致癌早期效应研究”(2012-2016),负责人。
6. 国家自然科学基金重大项目资助“大气二次污染形成的化学过程及其健康影响”(2012-2016),子课题负责人。
7. 科技部国家重点基础研究发展计划“消费品中纳米颗粒的健康效应研究”(2011-2015),子课题负责人。
8. 国家自然科学基金面上项目资助“职业接触铬盐对体内多元素影响及机制研究”,2010-2013,负责人。
9. 国家自然科学基金面上项目资助“不同尺寸纳米级二氧化钛对生产者健康效应的初步研究”(2008-2010),负责人。
10. 国家自然科学基金面上项目资助“铬盐接触者遗传易感性的研究”(2006-2008),负责人。
1. Jiayu Xu, Yu Liu, Qiaojian Zhang, Zekang Su, Tenglong Yan, Shupei Zhou, Tiancheng Wang, Xuetao Wei, Zhangjian Chen, Guiping Hu, Tian Chen, Guang Jia*. DNA damage, serum metabolomic alteration and carcinogenic risk associated with low-level air pollution [J]. Environ Pollut. 2022, 297:118763.
2. Guiping Hu, Changmao Long, Lihua Hu, Yali Zhang, Shiyi Hong, Qiaojian Zhang, Pai Zheng, Zekang Su, Jiayu Xu, Li Wang, Xiaoying Gao, Xiaojun Zhu, Fang Yuan, Tiancheng Wang, Shanfa Yu, Guang Jia*. Blood chromium exposure, immune inflammation and genetic damage: Exploring associations and mediation effects in chromate exposed population [J]. J Hazard Mater, 2022, 425: 127769.
3. Guiping Hu, Changmao Long, Lihua Hu, Benjamin Ping Xu, Tian Chen, Xiaoyin Gao, Yali Zhang, Pai Zheng, Li Wang, Tiancheng Wang, Lailai Yan, Shanfa Yu, Lijun Zhong, Wei Chen, Guang Jia*. Circulating lead modifies hexavalent chromium-induced genetic damage in a chromate-exposed population: An epidemiological study [J]. Science of the Total Environment, 2021, 752: 0-141824.
4. Zhangjian Chen, Pai Zheng, Shuo Han, Jiahe Zhang, Zejun Li, Shupei Zhou, Guang Jia*. Tissue-specific oxidative stress and element distribution after oral exposure to titanium dioxide nanoparticles in rats [J]. Nanoscale,2020, 12(38):20033-20046.
5. Zhangjian Chen, Di Zhou, Shuo Han, Shupei Zhou, Gaung Jia*. Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles [J]. Part Fibre Toxicol, 2019, 16(1): 48.
6. Guiping Hu, Ping Li, Xiaoxing Cui, Yang Li, Ji Zhang, Xinxiao Zhai, Shanfa Yu, Shichuan Tang, Zuchang Zhao, Jing Wang, Jia Guang*. Cr(VI)-induced methylation and down-regulation of DNA repair genes and its association with markers of genetic damage in workers and 16HBE cells [J]. Environ Pollut, 2018, 238: 833-843.
7. Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang, Guang Jia*. Cardiopulmonary effects induced by occupational exposure to titanium dioxide nanoparticles [J]. Nanotoxicology, 2018, 12(2): 169-184.
8. Yun Wang, Zhangjian Chen, Te Ba, Ji Pu, Tian Chen, Yanshuang Song, Yongen Gu, Qin Qian, Yingying Xu, Kun Xiang, Haifang Wang, Jia Guang*. Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium DioxideNanoparticles [J]. Small. 2013, 9(9-10): 1742-52.
9. Tiancheng Wang, Yanshaung Song, Haifang Wang, Ji Zhang, Shanfa Yu, Yongen Gu,Tian Chen, Yun Wang, Huiqi Shen, Guang Jia*. Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers [J]. J Hazard Mater, 2012, 213-214: 440-6.
10. Guang Jia, Haifang Wang, Lei Yan, Xiang Wang, Rongjuan Pei, Tao Yan, Yuliang Zhao, Xinbiao Guo. Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene [J]. Environ Sci Technol, 2005, 39 (5): 1378-1383.