Reproductive health epidemiology

Molecular epidemiology

Precision nutrition

1. Major Project of the National Social Science Fund of China (21&ZD187), 2022-2024, Principal Investigator of Sub-project

Ÿ2. National Key Research and Development Program of China systematic identification of pathogenic mutations of major birth defects (2021YFC2701101), 2022-2024, PI of a sub- project

Ÿ3. National Natural Science Foundation of China, Somatic mutation in fetal central nervous tissue and neural tube defects, 2018-2021, Principal Investigator

Ÿ4. National Natural Science Foundation of China, Association of rare variants and aberrant DNA methylation in PCP pathway with anencephaly, 2015-2018, Principal Investigator

Ÿ5. National Natural Science Foundation of China, Association between autoantibodies to folate receptors and the risk of neural tube defects, 2013-2015, Principal Investigator

6. National Key Research and Development Program, Ministry of Science and Technology, Key links of abnormal development of vital organs caused by environmental factors, 2016-2021, Co-investigator

Ÿ7. Beijing Natural Science Foundation, Aberrant DNA methylation of homeobox genes and neural tube defects, 2016-2018, Principal Investigator

Ÿ8. Fund for Doctor Station, Ministry of Education, Antoantibodies to folate receptor in pregnant mothers or fetus and folate levels, 2011-2013, Principal Investigator

 1. Tian T, Cao X, Chen Y, Jin L, Li Z, Han X, Lin Y, Wlodarczyk BJ, Finnell RH, Yuan Z, Wang LL, Ren A, Lei Y. Somatic and de novo Germline Variants of MEDs in Human Neural Tube Defects. Frontiers in Cell and Developmental Biology. 2021;9:463.

2. Yang W., Ni W., Jin L., Liu J., Li Z., Wang LL. and Ren A. Determination of organochlorine pesticides in human umbilical cord and association with orofacial clefts in offspring. Chemosphere. 2020;266:129188.

3. Yang W., Guo Y., Ni W., Tian T., Jin L., Liu J., Li Z., Ren A. and Wang LL. Hypermethylation of WNT3A gene and non-syndromic cleft lip and/or palate in association with in utero exposure to lead: A mediation analysis. Ecotoxicol Environ Saf. 2020;208:111415.

4. Tian T., Lei Y., Chen Y., Karki M., Jin L., Finnell R. H., Wang LL. and Ren A. Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. Hum Genet. 2020;139:1299-1314.

5. Huang Y., Lin S., Wang C., Pi X., Jin L., Li Z., Wang LL. and Ren A. Neural Tube Defects and ZIC4 Hypomethylation in Relation to Polycyclic Aromatic Hydrocarbon Exposure. Frontiers in Cell and Developmental Biology. 2020;8:582661.

6. Guo Y. N., Liu L. J., Ni W. L., Pan Y. Q., Chen Y. Y., Xie Q., Liu Y. Q., Jin L., Li Z. W., Ren A. G. and Wang LL. L. Uranium concentration in umbilical cord may increase the risk for orofacial clefts. Environ Res. 2020;182:109103.

7. Chen Y., Liu L., Ni W., Jin L., Li Z., Ren A. and Wang LL. Association between selected alkaline earth elements concentrations in umbilical cord and risk for cleft lip with or without cleft palate. Sci Total Environ. 2020;750:141735.

8. Ni W., Yang W., Yu J., Li Z., Jin L., Liu J., Zhang Y., Wang LL. and Ren A. Association between selected essential trace element concentrations in umbilical cord and risk for cleft lip with or without cleft palate: A case-control study. Sci Total Environ. 2019;661:196-202.

9. Ni W., Yang W., Jin L., Liu J., Li Z., Wang B., Wang LL. and Ren A. Levels of polycyclic aromatic hydrocarbons in umbilical cord and risk of orofacial clefts. Sci Total Environ. 2019;678:123-132.

10. Lin S., Ren A., Wang LL., Santos C., Huang Y., Jin L., Li Z. and Greene N. D. E. Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Clin Epigenetics. 2019;11:13.