Cellular and Computational Toxicology

Mechanisms of Drug Metabolism and Toxicity

Effects of air pollution under natural environment on human health

1. National Natural Science Foundation of China (No. 82174068), Identification of cinnabar’s target proteins by “target fishing” technique and study on the molecular mechanism underlying the neural effects of cinnabar (Role: PI)

2. The National Key Research and Development Program of China （No. 2018YFC1004301）， A cohort study of the effects of environmental and behavioral factors on embryonic development and maternal health based on external exposure monitoring   (Role: PI)

3. National Natural Science Foundation of China (No. 81673685), Study on potential developmental neurotoxicity of cinnabar and detoxification of pediatric medicine “Yinianjin”  (Role: PI)

4. Ph.D Programs Foundation of Ministry of Education of China (No. 20130001110065), Study on the molecular mechanism of bakuchiol’s CYP metabolism and toxicity   (Role: PI)

5. National Natural Science Foundation of China (No. 81341089), Study on the compatibility of Psoralea corylifolia with Licorice based on the metabolic interactions   (Role: PI)

6. National key Project of Science and technology for the 11th five-year plan of China (No. 2007BAC03A10), Health-based risk assessment of wind sand disaster in west China  (Role: Co-PI)

7. National Natural Science Foundation of China (No. 30672653), Study on the association between species transformation of cinnabar in gastrointestinal and its efficacy or toxicity (Role: PI)

1. Zhang T, Wang S, Li L, Zhu A, Wang Q*. Associating diethylhexyl phthalate to gestational diabetes mellitus via adverse outcome pathways using a network-based approach. Sci Total Environ. 2022, 824:153932

2. Yuqing Sun, Xin Zhang, Xiaofan Shen, Shuo Wang, Qi Wang*, Xiuwei Yang *. Computational and experimental characterization of isomers of escin-induced renal cytotoxicity by inhibiting heat shock proteins. Eur J Pharmacol, 2021, 908:174372

3. Jingwei Zhao, An Zhu, Yuqing Sun, Wenjing Zhang, Tao Zhang, Yadong Gao, Danping Shan, Shuo Wang, Guojun Li, Kewu Zeng*, Qi Wang*, Beneficial effects of sappanone A on lifespan and thermotolerance in Caenorhabditis elegans. Eur J Pharmacol, 2020, 888: 173558

4. Mimi Yang, Lichao Wang, Tao Zhang, An Zhu, Yuqing Sun, Jingwei Zhao, Dan Liu, Qi Wang*, Kewu Zeng*. Different proteomic profiles of cinnabar upon therapeutic and toxic exposure reveal distinctive biological manifestations. J Ethnopharmacol, 2020, 112668.

5. An Zhu, Zonghui Ji, Jingwei Zhaoa, Wenjing Zhangb,c, Yuqing Suna, Tao Zhanga, Shan Gaob, Guojun Li*, Qi Wang*. Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans. Phytomedicine，2019, 65: 153102

6. Jinlan Yang, An Zhu, Shuo Xiao, Tao Zhang, Liming Wang, Qi Wang*, Lifeng Han*. Anthraquinones in the aqueous extract of Cassiae semen cause liver injury in rats through lipid metabolism disorder. Phytomedicine，2019, 64: 153059

7. Yuqing Sun, Shaoze Shi, Yaqiu Li, Qi Wang*. Development of quantitative structure-activity relationship models to predict potential nephrotoxic ingredients in traditional Chinese medicines. Food Chem Toxicol, 2019, 128: 163-170

8. An Zhu, Yuqing Sun, Qianwen Zhong, Jinlan Yang, Tao Zhang, Jingwei Zhao, Qi Wang*. Effect of Euphorbia factor L1 on oxidative stress, apoptosis and autophagy in human gastric epithelial cells. Phytomedicine，2019, 64: 152929 

9. An Zhu, Tao Zhang, Qi Wang*. The phytochemistry, pharmacokinetics, pharmacology and toxicity of Euphorbia semen. J Ethnopharmacol, 2018, 227: 41-55  

10. Xiaojing Hu, Youbo Zhang, Lei Zhang, Qi Wang*, Xiu-Wei Yang*. Metabolic detoxification of bakuchiol is mediated by oxidation of CYP 450s in liver microsomes. Food Chem Toxicol, 2018, 111: 385-392