中文

Faculty

Zhangjian Chen

Zhangjian Chen

Zhangjian Chen

  • Assistant Professor, Associate research fellow
  • zhangjianchen@bjmu.edu.cn
  • Xueyuan Road 38, Haidian District, Beijing, China
  • Peking University
Personal profile

Bachelor of Medicine in Preventive Medicine, from School of Public Health, Peking University in 2006-2011. Ph.D. from the Department of Occupational and Environmental Sciences, School of Public Health, Peking University in 2011-2016. Since 2016, I have been working at Peking University through the Outstanding Doctoral Program. Hosted and participated in a number of national research projects. A series of my papers were published in the high-quality journals, such as Particle and Fibre Toxicology, Nanoscale, Nanomedicine (NBM), Toxicology Letters, Science of the Total Environment etc. Meanwhile, I am a reviewer for Nanoscale, Particle and Fibre Toxicology, Science of the Total Environment, Toxicology Letters, Environmental Science and Pollution Research and Environmental and Occupational Medicine (Chinese).


Main research directions

Nanotoxicology, Occupational Health, Environmental Health, Heavy Metal Toxicology.

Representative scientific research projects

1.National Natural Science Foundation of China (81703257): The effect of titanium dioxide nanoparticles on the gut microbiota in rats after low-dose and long-term oral exposure;

2.National Science and Technology Major Project of the Ministry of Science and Technology of China (2017YFC1600204): Hazard identification and toxicity models of typical pollutants and potential risk substances in food; ADME research and biosafety evaluation method of nanomaterials in foods (The fourth sub-project);

3.National Basic Research Program of China (973 Program, 2011CB933402): Research on mechanism of biological effects and safety evaluation of important nanomaterials; Research on the health effects of nanoparticles in consumer products (The second sub-project);

4.National Science and Technology Support Program (2014BAI12B04): Control of occupational exposure to medical radiation and health hazards of heavy metals and nanomaterials;

5.National Natural Science Foundation Major Research Program of China (Cultivation Project, 91743114): Effects of PM2.5 and effective components on damage and repair of genetic material in rats.

 

10 representative papers

1. Chen Z, Han S, Zhang J, Zheng P, Liu X, Zhang Y, Jia G*. Exploring urine biomarkers of early health effects for occupational exposure to titanium dioxide nanoparticles using metabolomics. Nanoscale. 2021, 13(7), 4122-4132.

2. Chen Z, Han S, Zhang J, Zheng P, Liu X, Zhang Y, Jia G*. Metabolomics screening of serum biomarkers for occupational exposure of titanium dioxide nanoparticles. Nanotoxicology. 2021, 15(6), 832–849.

3. Chen Z, Zheng P, Han S, Zhang J, Li Z, Zhou S, Jia G*. Tissue-specific oxidative stress and element distribution after oral exposure to titanium dioxide nanoparticles in rats. Nanoscale. 2020, 12(38):20033-20046.

4. Chen Z1, Han S1, Zhou D, Zheng P, Zhou S, Jia G*. Serum metabolomic signatures of Sprague-Dawley rats after oral administration of titanium dioxide nanoparticles. Nanoimpact, 2020, 19:100236.

5. Chen Z, Han S, Zhou S, Feng H, Liu Y, Jia G*. Review of health safety aspects of titanium dioxide nanoparticles in food application. Nanoimpact, 2020, 18:100224.

6. Chen Z, Han S, Zheng P, Zhou D, Zhou S, Jia G*. Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats. Nanoscale, 2020, 12(10): 5973-5986.

7. Chen Z, Han S, Zheng P, Zhou S, Jia G*. Combined effect of titanium dioxide nanoparticles and glucose on the blood glucose homeostasis in young rats after oral administration. Journal of applied toxicology, 2020, 39(4):590-602.

8. Chen Z, Zhou D, Han S, Zhou S, Jia G*. Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles. Particle and fibre toxicology, 2019, 16(1): 48.

9. Chen Z, Han S, Zhou D, Zhou S, Jia G*. Effects of oral exposure to titanium dioxide nanoparticles on gut microbiota and gut-associated metabolism in vivo. Nanoscale, 2019, 11(46): 22398-22412.

10. Chen Z1, Cui L1, Cui X, Li X, Yu K, Yue K, Dai Z, Zhou J, Jia G*, Zhang J*. The association between high ambient air pollution exposure and respiratory health of young children: A cross sectional study in Jinan, China. Science of the Total Environment, 2019, 656: 740-749.