The current researches are mainly focused on adverse effect of occupational and environmental factors. The majority of the work is devoted to identifying the health impact of nanoparticles, understanding toxicity characteristics and exploring their mechanisms.
1. National Natural Science Foundation of China (31971313), Effects of titanium dioxide nanoparticles on the occurrence and development of colorectal carcinoma and its mechanism,2020.1-2023.12. PI.
2. Beijing Natural Science Foundation (7172116), The impact of titanium dioxide nanoparticles on inflammatory bowel disease: role of oxidative stress and antioxidant therapy, 2017.1-2019.12. PI
3. National Natural Science Foundation of China (31400863), The effect and mechanism of TiO2 nanoparticles on intestinal mucosal barrier dysfunction, 2015.1-2017.12. PI
4. Beijing Natural Science Foundation (7132117), Effect of titanium dioxide nanoparticles on glucose absorption and metabolism, 2013.1-2015.6. PI
5. National Key R&D Program of China (2016YFC0206506), Study on the Influence of Air Pollution Intervention on the Exposure Response of Acute Health Effects in Population. 2016.7-2020.6. Member
6. National Basic Research Program of China (973 Program, 2011CB933402), Study on the mechanism of biological effects and safety evaluation of special nanomaterials. 2011.1-2015.8. Member
Yongliang Zhang, Shumin Duan, Ying Liu, Yun Wang*. The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs. Particle and Fibre Toxicology, 2021, 18, 8.(IF2020=9.400)
Yanjun Gao, Tingyu Li, Shumin Duan, Lizhi Lv, Yuan Li, Lin Xu, Yun Wang*. Impact of titanium dioxide nanoparticles on intestinal community in the 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced acute colitis mice and the intervention effect of vitamin E. Nanoscale, 2021, 13: 1842-1862.(IF2020=7.790)
Lizhi Lyu, Yuan Li, Xiaxian Ou, Wanqian Guo, Yi Zhang, Shumin Duan, Yanjun Gao, Yu Xu, Tianzhuo Yang, Yun Wang*. Health effects of occupational exposure to printer emissions on workers in China: Cardiopulmonary function change. NanoImpact, 2021, 21: 100289. (IF2020=5.316)
Yanjun Gao, Yixuan Ye, Jing Wang, Hao Zhang, Yao Wu, Yihui Wang, Lailai Yan, Yongliang Zhang, Shumin Duan, Lizhi Lv, Yun Wang*. Effects of titanium dioxide nanoparticles on nutrient absorption and metabolism in rats: distinguishing the susceptibility of amino acids, metal elements, and glucose. Nanotoxicology, 2020, 14(10): 1301-1323. (IF2020=5.913)
Alex P. Carll, Renata Salatini, Sandra V. Pirela, Yun Wang, Zhengzhi Xie, Pawel Lorkiewicz, Nazratan Naeem, Yong Qian, Vincent Castranova, John J. Godleski, Philip Demokritou*. Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats. Particle and Fibre Toxicology, 2020, 17: 7. (IF2020=9.400)
Sandra V. Pirela#, Kunal Bhattacharya#, Yun Wang#(co-first), Yipei Zhang, Guanghe Wang, Costas A. Christophi, John Godleski, Treye Thomas, Yong Qian, Marlene S. Orandle, Jennifer D. Sisler, Dhimiter Bello, Vincent Castranova, Philip Demokritou*. A 21-day sub-acute, whole-body inhalation exposure to printer-emitted engineered nanoparticles in rats: Exploring pulmonary and systemic effects. NanoImpact, 2019, 15: 100176. (IF2019=5.478)
Zhangjian Chen, Yun Wang*, Lin Zhuo, Shi Chen, Lin Zhao, Tian Chen, Yang Li, Wenxiao Zhang, Xin Gao, Ping Li, Haifang Wang, Guang Jia*. Interaction of titanium dioxide nanoparticles with glucose on young rats after oral administration. Nanomedicine: Nanotechnology, Biology and Medicine, 2015, 11(7): 1633-1642. (IF2015=5.671)
Zhangjian Chen#, Yun Wang# (co-first), Te Ba, Yang Li, Ji Pu, Tian Chen, Yanshuang Song, Yongen Gu, Qin Qian, Jinglin Yang, Guang Jia*. Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro, Toxicology Letters, 2014, 226(3):314-319. (IF2014=3.262)
Yun Wang, Zhangjian Chen, Te Ba, Ji Pu, Tian Chen, Yanshuang Song, Yongen Gu, Qin Qian, Yingying Xu, Kun Xiang, Haifang Wang, Guang Jia*. Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles. Small, 2013, 9(9–10): 1742–1752. (IF2013=7.514;Highlighted by Materials Views China from Wiley)
Yun Wang#, Bing Wang#, Motao Zhu, Ming Li, Huajian Wang, Meng Wang, Hong Ouyang, Zhifang Chai, Weiyue Feng*, Yuliang Zhao. Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticles exposure. Toxicology Letters, 2011, 205(1): 26-37. (IF2011=3.230)