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Guang Jia

Professor
jiaguangjia@bjmu.edu.cn
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

In 1990 and 1993, I obtained a bachelor's degree in preventive medicine and a master's degree in toxicology from Shandong Medical University (Shandong University). In 1996, I received my doctorate in occupational health from Beijing Medical University (Peking University) where I was promoted to professor in 2006. I was STA fellow at the National Institute of Environmental Studies in Japan from 2000 to 2002 and also had short-term visits at Toyama University and Kawasaki Medical University in Japan.

Main courses I lecture on include compulsory course "Occupational Health" for undergraduates, optional courses "Biomarkers and Biological Monitoring" and "Occupational Health Progress" for postgraduates, and I have been awarded the title of "Excellent doctoral dissertation instructor of Peking University" for three times in succession.

I am PI in several projects of the National Natural Science Foundation and the Ministry of Science and Technology. As first or corresponding author, I published nearly 70 original articles indexed by SCI, among which, the top citations of a single paper by Google nearly reach 3996 times until now，the total citation is 10517， h-indexis36，i10-index is104. I serve as the chief editors of “Occupational Health Course”, "Respiratory Toxicology", "Occupational Health and Occupational Medicine (Case Version)" and many other monographs or textbooks. Research results have contributed to the transformation of three items of Association Standards and one of National Standards.

I am deputy director of both Institutes of Environmental Medicine of Peking University and the Beijing Key Laboratory of Occupational Safety and Health; consultant expert of National Health Commission，the Ministry of Education, the Ministry of Science and Technology, and the Ministry of Ecology and Environment of China; also, member of the Academic Committee of the Occupational Health and Poison Control Institute of the National Center for Disease Control and Prevention. I am vice chairwoman of Occupational Health and Occupational Diseases Committee of the Chinese Preventive Medicine Association, Free Radical Preventive Medicine Committee of the Chinese Preventive Medicine Association, the Industrial Toxicology Committee of the Chinese Society of Toxicology, the Biomarker Committee of the China Environmental Mutagen Society, and the Occupational Health Association Standards of the China Health Supervision Society, also, a member of the Health, Safety and Environment Working Group of the National Nanotechnology Standardization Technical Committee and Standing Committee of the Technical Committee of Occupational Health and Diseases of the Chinese Preventive Medicine Association. In addition, I work as the editor of several journals such as "Chinese Journal of Preventive Medicine" and "Environmental Health and Preventive Medicine".

Main research directions

Mechanism and Prevention of Occupational and Environmental Pollutants (including nano-toxicology research, health risk assessment of heavy metals, biological monitoring and biomarker research, and multi-omics technology Combined application).

Representative scientific research projects

1. Joint Fund of National Natural Science Foundation's key program, Study on Early Genetic Damage and Repair Mechanism of Occupational Exposure to Chromate Based on Immunoregulation (2021-2024), PI.

2. National Natural Science Foundation of China, Study on the Damage and Repair Mechanism of Respiratory System Induced by Occupational Chromate Exposure Based on Integrated Omics Technology (2019-2022), PI.

3. The National Natural Science Foundation's major research project, Effects of Atmospheric Particulate Matter (PM2.5) and its Efficient Components on the Damage and Repair of Genetic Material in Rats (2018-2020), PI.

4. National Natural Science Foundation of China, The Mechanism of Gene-environment Interaction on Chromate Induced Genetic Damage (2016-2019), PI.

5. The National Natural Science Foundation of China, Early Effects of Chromium Carcinogenesis Based on Molecular Exposome (2012-2016), PI.

6. Sub-project of the National Natural Science Foundation's major project, The chemical process of the secondary pollution of the atmosphere and its health impact (2012-2016), sub-project leader.

7. Sub-project of the National Key Basic Research and Development Program of the Ministry of Science and Technology, Research on the Health Effects of Nanoparticles in Consumer Products (2011-2015), Sub-project leader.

8. National Natural Science Foundation of China, research on the effects and mechanisms of occupational exposure to chromate on multiple elements in the body, (2010-2013), PI.

9. National Natural Science Foundation of China, preliminary study on the health effects of different sizes of nano-titanium dioxide on producers (2008-2010), PI.

10. National Natural Science Foundation of China, Research on Genetic Susceptibility of chromate Contactors (2006-2008), PI.

10 representative papers

1. Jiayu Xu, Yu Liu, Qiaojian Zhang, Zekang Su, Tenglong Yan, Shupei Zhou, Tiancheng Wang, Xuetao Wei, Zhangjian Chen, Guiping Hu, Tian Chen, Guang Jia*. DNA damage, serum metabolomic alteration and carcinogenic risk associated with low-level air pollution [J]. Environ Pollut. 2022, 297:118763.

2. Guiping Hu, Changmao Long, Lihua Hu, Yali Zhang, Shiyi Hong, Qiaojian Zhang, Pai Zheng, Zekang Su, Jiayu Xu, Li Wang, Xiaoying Gao, Xiaojun Zhu, Fang Yuan,Tiancheng Wang, Shanfa Yu, Guang Jia*. Blood chromium exposure, immune inflammation and genetic damage: Exploring associations and mediation effects in chromate exposed population [J]. J Hazard Mater, 2022, 425: 127769.

3. Guiping Hu, Changmao Long, Lihua Hu, Benjamin Ping Xu, Tian Chen, Xiaoyin Gao, Yali Zhang, Pai Zheng, Li Wang, Tiancheng Wang, Lailai Yan, Shanfa Yu, Lijun Zhong, Wei Chen, Guang Jia*. Circulating lead modifies hexavalent chromium-induced genetic damage in a chromate-exposed population: An epidemiological study [J]. Science of the Total Environment, 2021, 752: 0-141824.

4. Zhangjian Chen, Pai Zheng, Shuo Han, Jiahe Zhang, Zejun Li, Shupei Zhou, Guang Jia*. Tissue-specific oxidative stress and element distribution after oral exposure to titanium dioxide nanoparticles in rats [J]. Nanoscale,2020, 12(38):20033-20046.

5. Zhangjian Chen, Di Zhou, Shuo Han, Shupei Zhou, Gaung Jia*. Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles [J]. Part Fibre Toxicol, 2019, 16(1): 48.

6. Guiping Hu, Ping Li, Xiaoxing Cui, Yang Li, Ji Zhang, Xinxiao Zhai, Shanfa Yu, Shichuan Tang, Zuchang Zhao, Jing Wang, Jia Guang*. Cr(VI)-induced methylation and down-regulation of DNA repair genes and its association with markers of genetic damage in workers and 16HBE cells [J]. Environ Pollut, 2018, 238: 833-843.

7. Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang, Guang Jia*. Cardiopulmonary effects induced by occupational exposure to titanium dioxide nanoparticles [J]. Nanotoxicology, 2018, 12(2): 169-184.

8. Yun Wang, Zhangjian Chen, Te Ba, Ji Pu, Tian Chen, Yanshuang Song, Yongen Gu, Qin Qian, Yingying Xu, Kun Xiang, Haifang Wang, Jia Guang*. Susceptibility of Young and Adult Rats to the Oral Toxicity of Titanium DioxideNanoparticles [J]. Small. 2013, 9(9-10): 1742-52.

9. Tiancheng Wang, Yanshaung Song, Haifang Wang, Ji Zhang, Shanfa Yu, Yongen Gu,Tian Chen, Yun Wang, Huiqi Shen, Guang Jia*. Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers [J]. J Hazard Mater, 2012, 213-214: 440-6.

10. Guang Jia, Haifang Wang, Lei Yan, Xiang Wang, Rongjuan Pei, Tao Yan, Yuliang Zhao, Xinbiao Guo. Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene [J]. Environ Sci Technol, 2005, 39 (5): 1378-1383.