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Yangfeng Wu

Professor
wuyf@bjmu.edu.cn
Xueyuan Road 38, Haidian District, Beijing, China
Peking University

Personal profile

Professor Wu is the Executive Director of Peking University Clinical Research Institute. He has been principal investigators of tens of research projects sponsored by national and international founding agencies including China Ministry of Science and Technology, China Natural Science Foundation, the US National Institutes of Health, Australia National Health and Medical Research Council, the UK Medical Research Council, etc. He developed the first cardiovascular risk prediction model for Chinese population, chaired the writing group for Chinese Guidelines on Prevention and Control of Hypertension in Primary Care, and joined the writing groups of multiple Chinese guidelines in the area of cardiovascular disease prevention and control. He published over 260 scientific papers on peer-reviewed journals. He received many awards and honors, including those from the State Council, Ministry of Health, Chinese Medical Association, Chinese Preventive Medicine Association, etc. He is currently also the Chair of the Chinese Non-Public Healthcare Organizations Association Brunch on Chronic Disease Management, the Vice-Chair of the Committee of Health Risk Assessment and Control, Chinese Preventive Medicine Association, and the Director of Peking University-Asian Pacific Economy Council Regulatory Science Center of Excellence.

Main research directions

Causal risk factors of cardiovascular disease and effective interventions for prevention and control

Theory and methods in clinical research

Representative scientific research projects

1. (2016-2020)National Key R&D Project: Nutrition and behavior interventions for prevention of cardiovascular disease (MOST: #2016YFC1300200)

2. (2015-2017)National Nature Science Foundation Project: A cohort study on relationship of dietary factors and metabolomics to blood pressure (NSF: #81473044)

3. (2013-2018) The US NIH Project: Integrating Depression Care in Acute Coronary Syndromes Patients in Low Resource Hospitals in China (I-Care Study) (NIMH：1R01MH100332-01)

4. (2008-2013) The US NIH Project: China Rural Health Initiative (NHLBI&UHG：HSSN268200900027C）

5. (2007-2009) National Science and Technology Key Project: A follow-up study on pre-clinical atherosclerosis (MOST: 2006BAI01A02-01)

6. (2006) A double-blind, randomized controlled trial on the effect of combination therapy with fixed dose of statins and antagonist of cholesterol absorption in lowering serum cholesterol (Schering Plough)

7. (2005-2006) Effect of salt substitute in lowering blood pressure among patients with hypertension and their family members (China CDC- Danone Foundation)

8. (2005) A double-blind, randomized controlled trial on the effect of antagonist of cholesterol absorption in lowering serum cholesterol (Schering Plough)

9. (2004-2006) National Nature Science Foundation Project: An epidemiological study on the susceptibility genes of obesity among Chinese(NSF: #30471494)

10. (2004-2006) China Salt Substritute Study(CSSS): A double-blind randomized controlled trial on the efficacy and safety of long term use of salt substitute in lowering blood pressure (Capital Health Development Fund)

11. (2001-2006) National Science and Technology Key Project: Estimation and intervention of global cardiovascular risk among Chinese (MOST: 2004BA703B01 and 2001BA703B01)

(2001-2003) Beijing Science and Technology Key Project: Study on guidelines on detection, evaluation, prevention and management of hypertension (Beijing STC：#200100537）

(1996-2000) National Science and Technology Key Project: A study on trend of cardiovascular disease pandemic and prevention strategy in the 21st century (MOST: #96-906-02-01）

(1994-1997) National Nature Science Foundation Young Investigators Award: Study on the role of X-syndrome in developing cardiovascular disease among Chinese population (NSF: #39400068)

10 representative papers

1.Wu Y, Li S, Patel A, Li X, Du X, Wu T, Zhao Y, Feng L, Billot L, Peterson ED, Woodward M, Kong L, Huo Y, Hu D, Chalkidou K, Gao R for the CPACS-3 Investigators. Effect of a Quality of Care Improvement Initiative in Patients With Acute Coronary Syndrome in Resource-Constrained Hospitals in China - A Randomized Clinical Trial. JAMA Cardiol. doi:10.1001/jamacardio.2019.0897

2.Wu Y, Yin D, Abbasi K. China’s medical research revolution. BMJ 2018; 360: k547 doi: 10.1136/bmj.k547

3.Wu Y, Benjamin E, MacMahon S. Prevention and Control of Cardiovascular Disease in the Rapidly Changing Economy of China. Circulation, 2016(6): 133:2545-2560.

4.He F, Wu Y (co-first author), Feng X, Ma J, Ma Y, Wang H, Zhang J, Yuan J, Lin CP, Nowson C, MacGregor GA. School based education programme to reduce salt intake in children and their families (School-EduSalt): cluster randomised controlled trial. BMJ. Mar 18 2015, 350 :h770.

5.Wu Y, Huxley R, Li L, Anna V, Xie G, Yao C, Woodward M, Li X, Chalmers J, Gao R, Kong L, Yang X. The prevalence, awareness, treatment and control of hypertension in China: Data from the China National Nutrition and Health Survey (NNHS) 2002. Circulation. 2008, 118: 2679-2686.

6.China Salt Substitute Study Collaborative Group (corresponding author). Salt substitution: a low-cost strategy for blood pressure control among rural Chinese. A randomized, controlled trial. Journal of Hypertension, 2007, 25 (10):2011-2018.

7.Wu Y (corresponding author), Liu X, Li X, Li Y, Zhao L, Chen Z, Li Y, Rao X, Zhou B, Detrano R, Liu K for the USA-PRC Collaborative Study of Cardiovascular and Cardiopulmonary Epidemiology Research Group and the China Multicenter Collaborative Study of Cardiovascular Epidemiology (China MUCA) Research Group. Estimation of ten-year risk of fatal and non-fatal ischemic cardiovascular diseases in Chinese. Circulation. 2006,114:2217-2225.

8.Wu Y. Overweight and obesity in China: The once lean giant has a weight problem that is increasing rapidly（editorial）. BMJ. 2006, 333（7564）:362-363.

9.Zhang L, Yang J, Hong Z, Yuan G, Zhou B, Zhao L, Huang Y, Chen J, Wu Y (corresponding author). Proportion of different subtypes of stroke in China. Stroke 2003, 34(9): 2091-2096.

10.he study group on guidelines on detection, evaluation, prevention and management of hypertension (corresponding author). Guidelines on prevention and control of hypertension in primary care. Chinese General Practice. 2003, 2:3-5. (series)